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The preprocessing of diffusion MRI (dMRI) involves numerous steps to clean and standardize the data before fitting a particular model. Generally, researchers create ad-hoc preprocessing workflows for each dataset, building upon a large inventory of available tools. The complexity of these workflows has snowballed with rapid advances in acquisition and processing. dMRIPrep is an analysis-agnostic tool that addresses the challenge of robust and reproducible preprocessing for whole-brain dMRI data. dMRIPrep automatically adapts a best-in-breed workflow to the idiosyncrasies of virtually any dataset, ensuring high-quality preprocessing without manual intervention. dMRIPrep equips neuroscientists with an easy-to-use and transparent preprocessing workflow, which can help ensure the validity of inference and the interpretability of results.

The workflow is based on Nipype and encompases a large set of tools from other neuroimaging package. This pipeline was designed to provide the best software implementation for each state of preprocessing, and will be updated as newer and better neuroimaging software becomes available.

dMRIPrep performs basic preprocessing steps such as head-motion correction, susceptibility-derived distortion correction, eddy current correction, etc. providing outputs that can be easily submitted to a variety of diffusion models.